![]() ![]() Synergy Grants are highly competitive, with only 34 out of 440 applications submitted being funded in 2020.Symbiota, LLC List of Employees There's an exhaustive list of past and present employees! Get comprehensive information on the number of employees at Symbiota, LLC. They enable a team of leading researchers to bring together complementary skills, ideas, knowledge and infrastructures to jointly explore some of the most exciting and challenging questions in modern science. This collaboration is now possible by the European Research Council with a Synergy-Grant!ĮRC Synergy Grants are a very highly awarded funding programme in Europe. The team agrees: "Only together we can succeed in developing an overall picture of the structure and function of plasmodesmata. Over the next six years, the scientists want to decipher the structure, the composition and the mechanism of the plasmodesmata. To this end, Wolfgang Baumeister has joined forces with three other research groups under the name SymPore ("Plasmodesmata as Symplasmic Pores for Plant Cell-to-Cell Communication"). With the help of cryoelectron tomography and by combining other state-of-the-art methods, it will be possible to understand the plasmodesmata. The latest methods developed by Wolfgang Baumeister at the MPIB are now expected to achieve a breakthrough in this field and thus help to obtain an overall structural picture of the plasmodesmata. Wolfgang Baumeister and his colleagues at the MPIB in Martinsried are worldwide leaders in the elucidation of complex structures at highest resolution - down to single molecules - by cryoelectron tomography. Plasmodesmata can be identified in the light microscope, but they can' t be examined in detail. ![]() Even conventional electron microscopes can only inadequately image these highly complex structures of plasmodesmata. The researchers know that the structures under investigation are smaller than the resolution limit of optical microscopes. They consist of probably hundreds of proteins and several lipid membranes. They have a diameter between 50 and 160 nanometers, with one nanometer corresponding to one millionth of a millimeter. "This is not least due to the fact that plasmodesmata are on the one hand too small, even for modern microscopy methods, and at the same time too large and complex for the usual structural elucidation," stresses Rüdiger Simon from the Institute of Developmental Genetics at the HHU. ![]() Among other things, they prevent viral proteins or RNA from passing from one cell to the next.īut how this happens exactly is still unknown. "Plasmodesmata control both the exchange of nutrients and messenger nutrients, as well as the exchange of genetic information and even of proteins". In contrast, plasmodesmata in plants are much more complex: "Plasmodesmata are probably the most important and least studied organelles of a plant cell with immense significance for all aspects of the plant," says Wolf B. In animals, this is partly done via protein complexes that form cell-connecting selective channels, so-called "gap junctions". Only in this way they can coordinate their tasks for the benefit of the whole organism. To do this, cells have to communicate with each other and exchange information. An organism consists of many differentiated cells, each of which has to perform different tasks. ![]()
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